[Arthrex Japan LLC] Started sales of “Angel BMC Kit”, a medical device for BMC adjustment that is applied to regenerative medicine for bones and cartilage, etc.
Arthrex Japan LLC Press release: September 25, 2024 Started sales of “Angel BMC Kit”, a medical device for BMC adjustment that is applied to regenerative medicine for bones and cartilage, etc. The first class III medical device in Japan that can adjust the concentration and automatically separate PRP and BMC Image
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https://prcdn.freetls.fastly.net/release_image/96691/3/96691-3-017d8cd68cc9e0eb3822c3f1acb630ef-2811×1961.png Arthrex Japan LLC (Headquarters: Shinjuku-ku, Tokyo, Executive Officer: Yoshitaka Sarasawa) will release the “Angel cPRP/BMC System (hereinafter referred to as the Angel System)”, a highly functional PRP adjustment system that can adjust the concentration of PRP, in November 2023. It’s on sale starting this month. We will begin selling the “Angel BMC Kit” compatible with the same system nationwide from October 2024. The “Angel BMC Kit” has been approved for manufacture and sale as a medical device that can process a patient’s bone marrow fluid and adjust BMC (Bone Marrow Concentrate). This makes it the first class III medical device in Japan that can adjust the
concentration and automatically separate PRP and BMC. What is BMC (concentrated bone marrow fluid)? Bone marrow fluid contains a large number of various factors, including cells and growth factors that work to regenerate bones and blood vessels, and BMC is a substance that increases the therapeutic effect by increasing the concentration of these factors. It is used to treat diseases of the musculoskeletal system in anticipation of the combined effects of BMC cells and proteins such as growth factors. Among them, it has a high affinity for bones and cartilage, and is attracting attention as a regenerative medicine for diseases of bones, cartilage, and tendon attachment sites (the places where tendons attach to bones). The following is an overview of the main components contained in BMC that are considered effective for treatment and their main functions. Main cells included in BMC Bone marrow-derived mesenchymal stem cells (BM-MSCs) It has the ability to differentiate into tissues such as bone, fat, tendon, nerve, interstitium, and blood vessels. Mesenchymal stem cells can also be collected from fat and umbilical cord tissues, but BM-MSCs have a particularly high affinity for bone and cartilage treatment, and their application is being researched. Vascular endothelial progenitor cells (EPCs) They are known as cells that can differentiate into blood vessels, and are said to be able to repair or replenish damaged blood vessels. Other bone marrow mononuclear cells (BMNC) Bone marrow mononuclear cells are a general term that includes stem cells, progenitor cells, lymphocytes, monocytes, and other hematopoietic cells, including the cells listed above. Main proteins contained in BMC Platelet-derived growth factor (PDGF) Stimulates cell
proliferation Promotes angiogenesis, epithelial formation, and granulation tissue formation Suppresses the production of inflammatory components Transforming growth factor (TGF) Promotes extracellular matrix formation Regulates bone cell metabolism Suppresses the production of inflammatory components Bone morphogenetic protein (BMP) Promotes bone formation Induction of differentiation into cartilage, control of differentiation Vascular endothelial growth factor (VEGF) Promotes angiogenesis Promotion of inflammation Fibroblast growth factor (FGF) Promotes proliferation of endothelial cells and fibroblasts Stimulation of angiogenesis Interleukin-1 receptor antagonist (IL-1Ra) Suppression of inflammation Therapeutic fields in which BMC (concentrated bone marrow fluid) is expected In Japan, there are still few examples of this treatment, and opinions regarding its results are not consistent, so it has not yet been established as a treatment method. However, in Europe and the United States, it has already been clinically applied in multiple fields. We will introduce the main treatment methods for the main applications in the field of orthopedics. Injection treatment in the outpatient clinic Treatment purpose General treatment methods Treatment of osteoarthritis Inject BMC into the joint with a syringe. Treatment of intractable tendon diseases (tennis elbow, Achilles tendinopathy, etc.) Inject the BMC with a syringe into the tissue joint. Regenerative medicine surgery Treatment purpose General treatment methods Treatment of BML (abnormal bone marrow shadow) associated with osteoarthritis and osteochondral damage, treatment of idiopathic osteonecrosis As a surgical treatment, BMC is injected into the bone using a syringe. This treatment is Bone regenerative medicine “IOBP” It is said that Treatment of
pseudarthrosis (intractable fracture treatment) As a surgical treatment, artificial bone and BMC are mixed and transplanted between the fractured bones. Improving surgical outcomes (improving treatment outcomes for rotator cuff repair and anterior cruciate ligament reconstruction) BMC is injected into the affected area and
reconstructed tissue during surgery. Regenerative medicine for bones, joints, and muscles The following website provides easy-to-understand explanations of regenerative medicine in orthopedic surgery for patients.
https://prcdn.freetls.fastly.net/release_image/96691/3/96691-3-7b60837249ada7c93567e218b220d71e-2918×542.png Click here for the site ▶︎ Regenerative medicine for bones, joints, and muscles Explanation of terms PRP (Platelet-Rich Plasma): In Japanese, it is called platelet-rich plasma, which refers to plasma that contains a lot of platelets. BMC (Bone Marrow Concentrate): In Japanese, it is called concentrated bone marrow fluid, and it refers to bone marrow fluid that contains cells that regenerate bones and blood vessels, as well as various factors including growth factors, which are concentrated and separated from red blood cells. About Arthrex Arthrex is a global medical device manufacturer that is a leading company in product development and medical education in the field of orthopedics. Our corporate philosophy is “Helping Surgeons Treat Their Patients Better(TM).” As a pioneer in the field of arthroscopy, we strive to improve minimally invasive surgical techniques. , we have developed over 10,000 innovative products and surgical techniques. About Arthrex Japan LLC Arthrex Japan LLC is the Japanese subsidiary of Arthrex Inc., headquartered in Florida, USA, and provides treatment solutions in the field of sports orthopedics. [Company Profile] Arthrex Japan LLC Representative: Yoshitaka Sarasawa URL:
(http://www.arthrex.co.jp) Established: July 2009 Address: 28th floor, Shinjuku NS Building, 2-4-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo Business content: Manufacture/import/sale of medical devices and instruments
Contact information regarding this release Email address:
JPMarketing@Arthrex.com Phone number: 03-4578-1000 (Reception hours: 9:00 to 18:00) Sales name Approval number Common name Regulatory classification Functional classification Angel cPRP/BMC system 30500BZX00054000 Blood component separation kit Class III Not applicable *This release has been created for the purpose of providing information about our company’s activities to members of the press. Please note that this site is not intended to provide information to the general public or advertise products.