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POLA Birth of “Wrinkle Shot Medical Serum Duo”

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【POLA】 Birth of “Wrinkle Shot Medical Serum Duo” ​
Paula Press release: October 3, 2024 “Wrinkle Shot Medical Serum Duo” is born Siwa, be surprised. Neil One (R) *1 in all directions. Advance*2 beauty serum containing Neal One (R), an effective wrinkle-improving ingredient POLA Co., Ltd. (Headquarters: Shinagawa-ku, Tokyo, President and CEO: Miki Oikawa) has announced the release of Wrinkle Shot Medical Serum Duo (A formulation), an advanced serum containing the wrinkle-improving active ingredient Neal-One (R), from the Wrinkle Shot brand. 1.5mL x 2, B agent 13.5mL x 2, nozzle/body cap x 2 ¥19,800 ) will be released on January 1, 2025. This time, POLA has newly focused on the fact that there are scattered wrinkles that are difficult to notice, but exist in various parts of the face, and that neutrophil elastase, which is a contributing factor to wrinkles, is present on the entire face. Therefore, we took on the challenge of creating a formulation that delivers the active ingredient Neal One (R) to the entire face with a pleasant amount of moisture. The Department of Wrinkle Improvement Medicine overcame various obstacles to deliver the delicate Neal-One (R), which slowly breaks down when it comes in contact with water, to the entire face, becoming the first in Japan*3 to use the two agents by mixing them yourself. We have developed an external beauty serum. ◆Main features of “Wrinkle Shot Medical Serum Duo” [Skin you want] Improves wrinkles and leaves your skin smooth, moisturized, and supple. [Ingredients] Contains POLA’s proprietary wrinkle-improving active ingredient “Neil-One (R).” NeilOne(R) suppresses the action of neutrophil elastase, which breaks down collagen, which is a
contributing factor to wrinkles, and improves firmness and elasticity by aligning collagen fibers in the dermis, improving wrinkles. Contains new POLA original complex moisturizing ingredients
“NERENERGY*4”, “D LIQUID*5”, and POLA’s original complex moisturizing ingredient “NERE Liquid N*6”. [Feel] A moist fresh texture that spreads smoothly and smoothly and quickly blends into the entire face. [Prescription] 1. Equipped with POLA’s unique Wrinkle Shot Mix prescription, which allows you to mix the two agents yourself to use the wrinkle-improving active ingredient NeilOne (R) in a fresh texture that is easy to apply to the entire face. By mixing it yourself, you can achieve both a fresh feel and ease of use with items you use later. 2. Veil design that creates a firm veil with the aim of creating a smooth and smooth finish. Furthermore, it contains a moist catcher. A veil that provides moisture, keeps the moisture inside the veil, and allows items to be used later to blend easily. Pola Beauty Director nationwide, cosmetics & beauty shop “Pola the Beauty” Approximately 2,700 stores, including approximately 470 stores, the flagship store “POLA GINZA”, and 83 stores in POLA corners such as famous department stores nationwide. 11 Japanese airport duty-free shops, Pola official online store ( https://www.pola.co.jp/ec/

). (As of the end of December 2023) Overseas, it will be released
sequentially at duty-free stores in seven countries and regions: China (cross-border e-commerce), Hong Kong, Taiwan, Macau, Thailand, Singapore, and Malaysia, as well as South Korea and Australia. Released on January 1, 2025 Wrinkle Shot Medical Serum Duo
https://prcdn.freetls.fastly.net/release_image/36737/608/36737-608-523de953f4a3b8837059346ca198ada1-479×607.jpg Sales name: POLA Wrinkle Shot Medical Serum Duo [Quasi-drug] (Beauty serum) Active ingredient: Neil One (R) (wrinkle improvement) ¥19,800 (¥18,000 excluding tax) Agent A 1.5mL x 2 B agent 13.5mL×2 Nozzle/body cap ×2 ◆Allergy tested (not all people will not have allergies) *1: Sodium trifluoride isopropyloxopropylaminocarbonylpyrrolidine carbonylmethylpropylaminocarbonylbenzoylaminoacetate *2: Use after face wash and before lotion *3: First approved as a two-drug combination anti-wrinkle quasi-drug in March 2024 *4: Composite ingredient of birch extract and eucalyptus extract *5: Composite ingredient of Kouki extract-2 and linden extract *6: Compound ingredient of oil-soluble peach leaf extract and horsetail extract

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