Kubota Pharmaceutical Holdings Co., Ltd. Positive post hoc analysis announced for Phase 3 clinical trial

Kubota Pharmaceutical Holdings Co., Ltd.
Positive post-hoc analysis presented for Phase 3 clinical trial Emixustat hydrochloride, a drug candidate for the treatment of Stargardt’s disease

Kubota Pharmaceutical Holdings Co., Ltd. (Headquarters: Chiyoda-ku, Tokyo, hereinafter “the Company”) has announced that it will launch “Emixustat Hydrochloride” (hereinafter “Emixustat”) implemented by Kubota Vision Inc. (Headquarters: Washington, USA), a wholly owned subsidiary of the Company. ) for the indication of Stargardt’s disease.
The primary endpoint of this clinical trial includes verification of the efficacy in suppressing the progression of macular atrophy lesions in patients with juvenile macular degeneration Stargardt’s disease. There were no results demonstrating statistical significance for the emixustat-treated group compared with Subsequent further analysis suggested a significantly lower rate of progression of atrophic lesions in the emixustat group compared to placebo in the group of subjects with smaller baseline atrophic lesion area (mm2). , we conducted a subgroup analysis (*1) to verify this. We performed univariate and multivariate analyzes by attrition on the group of subjects with small baseline atrophic lesion area to identify independent baseline factors influencing the progression of atrophic lesions in this subgroup. The analysis showed that the progression rate of macular atrophy at 24 months in the emixustat group was 40.8% compared to the placebo group.
%reduced (p=0.0206, emixustat n=34, placebo n=21).

This material has been prepared for the sole purpose of disclosing relevant information and does not constitute a solicitation or offer to acquire or sell securities. This document has been carefully prepared for accuracy, but completeness is not guaranteed. In preparing this material, we relied on third-party information available to us, but we do not represent or guarantee the actual accuracy or completeness of such third-party information. Our company does not take any responsibility for any damage caused by relying on the descriptions in this document. Information in this document is subject to change without notice. This document contains
forward-looking information regarding future forecasts. These statements are based on current expectations, forecasts and risky assumptions, including but not limited to general economic and industry or market conditions, and may differ materially from actual performance. There is a possibility. future, new information, future We undertake no obligation to update or revise any forward-looking statements in this material, whether for events or otherwise. Details about this release:


Leave a Reply

Your email address will not be published.

%d bloggers like this: