Dr. Ci:Labo Discovered the effect of promoting gene expression of firmness and elasticity in Japan’s first compounded ingredient “penetrating collagen EX”! Confirmed to maintain higher penetration and collagen quality

Dr. Ci:Labo
Discovered the effect of promoting the gene expression of firmness and elasticity in Japan’s first compounded ingredient “penetration type collagen EX”! Confirmed to maintain higher penetration and collagen quality

Since its founding, Dr. Ci:Labo has focused on the importance of collagen, which holds the key to skin sagging and aging, and has continued research for over 20 years. Now that the mask life has been prolonged, the number of people suffering from loose mouth and wrinkles around the eyes has increased rapidly, and it has been found that the number of people suffering from “sagging face” has tripled since 2020. In order to solve the problems arising from the background of this era, through collagen research that has continued since the company was founded, Japan’s first combination combination
“Penetrating Collagen EX” was born. We discovered that this ingredient has the effect of promoting the gene expression of firmness and elasticity, and that it has high penetration power and ability to maintain the quality of collagen. Cosmetics launched this fall make use of this research approach.
“Penetrating Collagen EX” was born based on knowledge gained from over 20 years of research and advanced collagen science.
Pursuing collagen for more than 20 years, it was developed with its knowledge and advanced research, and was born with Japan’s first combination. It has a high penetrating power, maintains the quality of collagen by suppressing “carbamylation”, which is one of collagen deterioration, and promotes the expression of firmness and elasticity genes.
Research results of Japan’s first compounding ingredient “permeable collagen EX” 1⃣ Promotes the expression of genes that promote firmness and resilience It was found to increase gene expression of collagen, hyaluronic acid, and elastin. This is a command to synthesize ingredients related to firmness and elasticity, and the switch button is pressed more than usual, increasing the amount of firmness and elasticity ingredients in the skin. By approaching firmness and elasticity at the genetic level, it gives plump firmness from the inside.
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■ Test implementation date: March-April 2022 ■ Test method: Add the test product to pre-cultured human keratinocytes and fibroblasts, culture for 24 hours, and measure mRNA expression levels using real-time PCR. evaluated.
2⃣ Adjust molecular weight for deeper penetration
It’s not just that the molecular weight should be small, but it is adjusted to a molecular weight that penetrates deep into the skin and stays. It is a deeply penetrating ingredient.
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■ Testing institution name: Technoble Co., Ltd. ■ Test date: December 2006 ■ Test name: Hydrolyzed collagen permeability test ■ Test method: Hydrolyzed collagen is labeled with a green fluorescent labeling agent , was added to a three-dimensional model of cultured cortex
(TOYOBO/TESTSKINLSE-high). Three days after the addition, the three-dimensional model of the cultured cortex was fixed with formalin and sectioned. Then, the prepared sections were observed with a fluorescence microscope.
3 ⃣ Suppresses collagen deterioration “carbamylation”
Carbamylation is a phenomenon in which collagen deteriorates and softens. It was confirmed that the shiitake extract contained in the permeable collagen EX suppresses this carbamylation, thereby maintaining the quality of the collagen.
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■Test institute name: Lipotec(TM) Active ingredients, Lubrizol■Test implementation date: 18 December 2015■Test name: Evaluation of carbamylation on type I collagen■Test method: 20 ug/mL Type 1 Collagen with 0.1 M potassium cyanate to induce carbamylation, treated with LENTINUS EDODES EXTRACT or left untreated as a control, and
carbamylation was assessed.
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3 times: July 2020 survey “Questionnaire about changes in awareness of skin accompanying the new lifestyle of With Corona” N = 601 women, August 2021 survey “Skin awareness of the new lifestyle of With Corona Questionnaire about changes in consciousness” N = 600 females / Both surveyed by Dr. Ci:Labo First in Japan: First combination of three components of permeable collagen EX in cosmetics Permeable collagen EX: hydrolyzed collagen, acetyl hexapeptide-8, shiitake mushroom Extract (skin conditioning ingredient)
Details about this release:
https://prtimes.jp/main/html/rd/p/000000568.000002961.html


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One thought on “Dr. Ci:Labo Discovered the effect of promoting gene expression of firmness and elasticity in Japan’s first compounded ingredient “penetrating collagen EX”! Confirmed to maintain higher penetration and collagen quality

  1. Can you tell us more about this? I’d love to find out some additional information.

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