Natural Science Co., Ltd. Pregnant body cream (Mama & Kids Natural Mark Cream) was used by pregnant women to improve the skin dryness score, stratum corneum moisture content, transepidermal moisture loss, sebum content, and skin elasticity. Report

Natural Science Co., Ltd.
Pregnancy Body Cream (Mama & Kids Natural Mark Cream) for Pregnant Women Reported Significant Improvements in Dryness Score, Stratum corneum Moisture Volume, Percutaneous Moisture Loss, Sebum Volume, and Skin Elasticity

Natural Science Co., Ltd. (Headquarters: Chuo-ku, Tokyo, President: Reiko Komatsu), a skin care manufacturer for sensitive skin, has focused on the importance of skin care with moisturizing agents that can be used safely even during pregnancy. A study was conducted to examine the The results of this research were published in the historical medical article/medical information submission journal “Shinryo to Shinyaku”.
Pregnancy is reported to cause major changes in the body shape, endocrine metabolism system, blood vessels, immune system, etc. of the mother’s body, as well as changes in the skin, such as dryness and exacerbation of atopic dermatitis. Therefore, skin care with moisturizing agents that can be safely used even during pregnancy is considered important.
In this study, 31 healthy pregnant women (ages 25-43) up to the 32nd week of pregnancy were given a non-scented, hypoallergenic, highly moisturizing body cream (Mama & Kids Natural Mark Cream) for 4 weeks. , was used twice in the morning and evening, and safety and usefulness were examined. The test items consisted of skin findings, equipment measurements, and a questionnaire survey by a dermatologist, and a before-and-after comparison was made at the start of the test and after 4 weeks.
As a result, a significant improvement in the dryness score was observed in the skin findings, and a significant change in the stratum corneum water content and transepidermal water loss was also observed in instrumental measurements. In addition, there were no adverse events due to the use of the test product. Based on these findings, the test product, the body cream, can be safely used during pregnancy and is considered useful for maintaining healthy skin in pregnant women.
Thirty-one healthy pregnant women (ages 25 to 43) up to 32 weeks of gestation were asked to use moisturizing cream twice in the morning and evening for 4 weeks, and the results before and after 4 weeks were compared. Significant improvements were observed in skin dryness score, stratum corneum water content, transepidermal water loss, sebum content, and skin elasticity. In addition, there were no adverse events due to the use of the test product.
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Table 1_Changes in skin findings scores

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Table 2_ Changes in skin thickness and skin density
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Table 3_Questionnaire results
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Fig.1_Changes in stratum corneum moisture content
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Fig.2_Changes in transepidermal water loss
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Fig. 3_ Changes in sebum volume
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Figure 4_Skin elasticity (return rate: R2)
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Fig.5_Ultrasound image of the abdomen

Continuous use of the test product for 4 weeks resulted in a significant increase in stratum corneum water content and sebum content, as well as a significant decrease in transepidermal water loss. It is thought that the stratum corneum water content and sebum content were increased, and the barrier function was improved. In addition, there were no adverse events, suggesting that this test product can be safely used to maintain healthy skin during pregnancy. *Test period: 4 weeks from March 2021 to April 2021
* Test product: The test product used was “Mama & Kids Natural Mark Cream” manufactured by Natural Science Co., Ltd. Fragrance-free, color-free, low-irritant cream containing moisturizing ingredients (hyaluronic acid, ceramide, amino acids), emollient ingredients (calendula oil, argan oil), centella asiatica extract, collagen, low-molecular-weight elastin, etc.
About the paper
Title: Examination of the safety and usefulness of body creams for pregnant women
Authors: Seiko Tanaka 1), Yutaka Koyano 1), Nozomi Ando 1), Misa Fujinami 1), Yoshizumi Sato 1), Reiko Komatsu 1), Takashi Koikeda 2) 1) Natural Science Co., Ltd. 2) Shiba Palace Clinic
Journal: “Clinical Practice and New Drugs” (2022; 59: 522-528) -reference-
About Natural Science Co., Ltd.
Natural Science, a skincare manufacturer for sensitive skin, conducts research, development, and sales of skincare and supplements that bring out the natural power of the skin, focusing on hypoallergenic skincare that can be used with babies. Especially, “Mama & Kids”, which is the center of the brand, has been developed with the cooperation of dermatologists, pediatricians, and obstetricians and gynecologists, and has achieved low irritation. In addition, in order to confirm its effectiveness, we conduct thorough quality checks, such as conducting clinical tests at university hospitals and dermatology departments.
What is Mom & Kids Natural Mark Cream?
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Mom & Kids Natural Mark Cream
A very popular cream for pregnancy body created with the cooperation of midwives and senior mothers. Fragrance-free, coloring-free, and hypoallergenic prescription that is great for delicate Japanese pregnant women.
You can apply it all over your body to care for elasticity,
flexibility and moisture.
Fragrance-free, coloring-free, hypoallergenic, paraben-free, mineral oil-free, petroleum surfactant-free.
▼Product details

Natural Science Co., Ltd. Company Profile
Trade name: Natural Science Co., Ltd.
Representative: Reiko Komatsu, President and Representative Director Head office: 1-22-11 Shinkawa, Chuo-ku, Tokyo
Location: 3-4-27 Kitasuna, Koto-ku, Tokyo
Established: August 8, 1996
Business: Planning, research, development, manufacturing, and sales of cosmetics, quasi-drugs, and toothpaste; planning, development, manufacturing, and sales of health foods and foods; planning, development, and sales of ecology and children’s products
Capital: 10,000,000 yen
[Inquiries from general customers]
Natural Science Co., Ltd.
TEL: 0120-122-783 (toll-free)

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