Nippon Trim Co., Ltd.
Regular drinkers of electrolyzed hydrogen water had low oxidative stress and good renal function indices.
Expected as a disease prevention measure that is easy to become a habit. Published in the scientific journal “Heliyon”
Nihon Trim Co., Ltd. (Headquarters: Osaka City, President: Chikao Tahara) and RIKEN (Headquarters: Wako City, President: Makoto Gonokami) are jointly developing electrolyzed hydrogen water (*1) for everyday use. A paper on low oxidative stress (*2) in drinkers was submitted to the general scientific journal “Heliyon” and published online on November 24, 2022.
*1 Electrolyzed hydrogen water: Drinking water that is weakly alkaline and contains molecular hydrogen, obtained by purifying and
electrolyzing tap water with a water conditioner.
*2 Oxidative stress: A state in which an excess of active oxygen that exceeds the antioxidant capacity of the body is generated, resulting in an imbalance and a tendency toward oxidation. Cells and tissues are damaged, and it is thought to be related to many diseases such as lifestyle-related diseases.
Oxidative stress is low in people who drink electrolyzed hydrogen water on a daily basis.
Antioxidant properties of electrolyzed hydrogen water were also confirmed for healthy subjects.
Electrolyzed hydrogen water is expected to be a disease prevention measure that is easy to continue and habitualize.
In this joint research between Nihon Trim and RIKEN, blood tests were conducted on healthy subjects who regularly consumed electrolyzed hydrogen water generated from a water purifier and those who did not, to investigate the differences. did. As a result, healthy people who drink electrolyzed hydrogen water on a daily basis (64 people between the ages of 30 and 59 who have been drinking 500 ml or more a day and 5 days or more a week for 6 months or more) are compared to healthy people who do not Compared to the 470 subjects who were sex-matched and sex-matched, oxidative stress in the blood was significantly lower, and renal function indicators were significantly better. It was also confirmed that the lower the oxidative stress, the lower the chronic inflammation marker (high-sensitivity CRP level) and the risk marker related to arteriosclerosis (LDL cholesterol level).
Research significance and purpose
It has been pointed out that various physical disorders and diseases are related to oxidative stress, and how we can prevent it in our daily lives is an issue. Continuation of a well-balanced diet and moderate exercise is recommended as prevention in daily life, but it has been pointed out that it is difficult to continue. Continuation and ease of habituation are important for prevention. Therefore, we focused on drinking water, which is recommended to drink 1.2 liters per day. Electrolyzed hydrogen water is generated by passing tap water, which is infrastructure, through a water purifier that can be easily connected to a faucet, so it is easy to continue and make a habit of taking it. On the other hand, electrolyzed hydrogen water has been reported to have antioxidant and anti-inflammatory properties through in vitro tests, cell tests, animal tests 1), 2), and drinking tests for type 2 diabetes patients. The effect on healthy humans (healthy subjects) was unknown. Therefore, the purpose of this study was to conduct a blood test on healthy subjects who continuously drink electrolyzed hydrogen water on a daily basis and those who do not, and compare the results.
(1) Continuous drinkers of electrolyzed hydrogen water had
significantly higher oxidative stress values (d-ROMs) and relative oxidative stress (OSI), which are indicators of oxidative stress in the blood, compared to non-drinkers (control group). 1A and 1B), and urea nitrogen (BUN), an indicator of renal function, was also significantly lower than non-drinkers (Fig. 1C).
Oxidative stress values (d-ROMs):
It reflects the total amount of peroxides, including the amount of hydroperoxide (ROOH), which is a metabolite oxidized by active oxygen and radicals in the blood.
Relative oxidative stress (OSI):
An index obtained by dividing the oxidative stress value (d-ROMs) by the antioxidant potential value (BAP) and multiplying by a factor of 8.85. It is a ratio that indicates the balance between oxidation and anti-oxidation, and the lower the value, the lower the oxidative stress and the better.
Urea Nitrogen (BUN): One index of renal function. A high number indicates a decline in renal function.
P: Significance probability (less than 0.05 is considered
(2) The relative oxidative stress (OSI) of the electrolyzed hydrogen water continuous drinking group showed a positive correlation with high-sensitivity CRP and blood LDL cholesterol levels (Fig. 2A, 2B). [Image 2
High-sensitivity CRP (hs-CRP): a marker of chronic inflammation LDL cholesterol: a risk marker associated with arteriosclerosis Filled circles: plot of values for each subject
r: Correlation coefficient (indicates degree of correlation) P: Significance probability (less than 0.05 is considered
It was also suggested that regular drinking of electrolyzed hydrogen water could reduce oxidative stress in the blood and improve renal function in healthy subjects.
We recruited healthy volunteers (ages 30 to 59) and conducted blood tests on a group that drank electrolyzed hydrogen water daily (64 people) and a group that did not (470 people), and compared the results.
Based on this research, oxidative stress can be reduced simply by replacing the drinking water of healthy people with electrolyzed hydrogen water and continuously drinking it. Therefore, electrolyzed hydrogen water is expected to be a disease prevention measure that can be easily made into a daily habit.
This research was funded by the Japan Science and Technology Agency (JST) Research Complex Promotion Program for the Development of Research Results, “Health ‘Ikiiki’ Compass Research Complex (core institution: RIKEN)” and Nippon Trim Co., Ltd. was made with the support of
Abstract of thesis
“Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults”
(Japanese translation: Antioxidant effect of continuous drinking of electrolyzed hydrogen water in healthy subjects)
Main joint research participants
Principal Investigator: Dr. Yasuyoshi Watanabe, Team Leader, RIKEN Center for Biosystems Dynamics Research
Collaborator: Takashi Mizuno, Senior Researcher, RIKEN Center for Biosystems Dynamics Research, Doctor of Medicine
Joint researcher: Shigeru Kabayama, Ph.D. (Agriculture), MD Office, Nihon Trim Co., Ltd.
▼This is an open access article, so you can view it from the link below (English site).
Heliyon is a peer-reviewed academic journal published by Cell Press, headquartered in the United States. Cell and Neuron are representative scientific journals of the publisher.
1): Japanese translation title “Alleviation of Chronic Stress Response by Antioxidant and Anti-Inflammatory Effects of Electrolyzed Hydrogen Water”
▼ Click here for details
https://www.nihon-trim.co.jp/wp/wp-content/uploads/2020/12/nwesrelease201228.pdf 2): Japanese translation title “Daily drinking of electrolyzed hydrogen water relieves abdominal pain by suppressing inflammation of the intestinal tissue in inflammatory bowel disease model rats. ~ Expected as a preventive measure for recurrent intestinal diseases ~” ▼ Click here for details
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