National University Corporation Okayama University
[Okayama University] Is systemic administration of prophylactic antibiotics (antibiotics) necessary after cataract surgery?
December 22, 2022
National University Corporation Okayama University
-Points of announcement-
The number of drug-resistant bacteria that are resistant to
antibiotics (antibiotics) is increasing worldwide, and it is predicted that the number of people who die from infection with drug-resistant bacteria will increase.
The World Health Organization (WHO) adopted an action plan on antimicrobial resistance in 2015, and the Japanese government formulated an antimicrobial resistance action plan in 2016, promoting the proper use of antimicrobials (do not use them unnecessarily, and to reduce usage).
During and after cataract surgery, intravenous antibiotics and oral administration have been used to prevent infection.
Regarding cataract surgery performed between April 2016 and October 2022, antibiotic drip and oral administration were discontinued in stages from January 2018, and oral administration was discontinued from November 2021. There was no infection.
From this survey, we show the grounds that postoperative infection will not occur if local infection control measures such as antibiotic eye drops are taken before surgery, and that systemic administration of antibiotics (infusion, oral administration) is unnecessary. I was able to.
National University Corporation Okayama University (Headquarters: Kita-ku, Okayama City, President: Hiroshi Makino) Faculty of Health System Integrated Science (Medicine) Department of Biofunction Regeneration and Reconstructive Medicine (Ophthalmology) Professor Toshihiko Matsuo, Faculty of Medicine and Dentistry In April 2016, Hidehiro Hagitani, associate professor of general internal medicine in the field of pharmacy (medicine), Masahiro Iguchi, pharmacist of Ochiai Hospital pharmacy in Maniwa City, Okayama Prefecture, Noriyasu Morisato, pharmacist, and Tatsuya Murase, Chief Technologist of the laboratory department, etc. ~ We looked back on 2149 cases of cataract surgery performed at Ochiai Hospital by October 2022, divided into five periods.
1. The period when the intravenous drip of antibiotics was performed during the operation and the oral administration was performed for 2 days after the operation
2. Period when oral antibiotics were taken from before surgery to 2 days after surgery
3. Time when other antibiotics were administered from preoperative to postoperative
4. Period when oral antibiotics were taken only once before surgery 5. Time when internal medicine was discontinued
No postoperative infection was observed during all five periods. From this survey, it can be said that systemic administration of antibiotics to prevent infection is not necessary in cataract surgery. The results of this research were published in the “International Journal of Environmental Research and Public Health”, a Swiss journal of environmental science and public health, on November 28, 2022. [Image 2
Status of systemic administration of antibiotics (infusion, oral administration) in the five periods in order from the oldest A word from Professor Toshihiko Matsuo
Dr. Hidehiro Hagitani, a specialist in infectious disease internal medicine, started an infectious disease learning / consultation meeting (O-CAST) for medical workers in Okayama Prefecture, and doctors, nurses, pharmacists, clinical laboratory technicians, etc. at public health centers and hospitals. A variety of medical
professionals and medical students are participating. As I
participated in this meeting and learned, I wondered whether systemic administration of antibiotics for infection prevention, which has been used for many years in eye surgery such as cataract surgery, is really necessary.
Around the year 2000, systemic administration of antibiotics was recommended in a lawsuit against postoperative infection
(endophthalmitis) after cataract surgery. I wish I could be the basis. [Image 3
Professor Toshihiko Matsuo
◆ Paper information
Title of thesis: Are Prophylactic Systemic Antibiotics Required in Patients with Cataract Surgery at Local Anesthesia?
Journal: International Journal of Environmental Research and Public Health Authors: Toshihiko Matsuo, Masahiro Iguchi, Noriyasu Morisato, Tatsuya Murasako, Hideharu Hagiya
◆ Detailed research content
Is systemic administration of prophylactic antibiotics (antibiotics) necessary after cataract surgery?
https://www.okayama-u.ac.jp/up_load_files/press_r4/press20221221-1.pdf ◆ Reference
・Graduate School of Integrated Sciences in Health Systems, Okayama University https://www.gisehs.okayama-u.ac.jp/
・Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
・Ophthalmology, Okayama University Hospital
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Okayama University Shikata Campus, where Okayama University Hospital is located (Kita Ward, Okayama City)
◆ Inquiries regarding this matter
Okayama University Academic Research Faculty Department of Integrated Health System Science (Medicine) (Ophthalmology, Okayama University Hospital) Professor Toshihiko Matsuo
Okayama University Shikata Campus, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama Prefecture 700-8558
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