National University Corporation Okayama University
[Okayama University] Discovery of a drug that increases the risk of immune checkpoint inhibitor-induced myocarditis! ～Returning real-world data to actual clinical practice～
July 30, 2023
National University Corporation Okayama University
https://www.okayama-u.ac.jp/
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Data science using medical information big data revealed that concomitant use of immune checkpoint inhibitors and thiazide diuretics increases the risk of myocarditis.
It was found that the concomitant use of immune checkpoint inhibitors and thiazide diuretics caused myocarditis even after excluding other factors (age, sex, concomitant use of other diuretics, etc.). . Diuretics play an important role in the treatment of cardiovascular events, and progress in research on the risk of side effects of each drug is expected to lead to the clarification of the optimal drug therapy for myocarditis.
◆Overview
Lecturer Hiroaki Hamano and Professor Yoshihito Zamami of the Department of Pharmacy, Okayama University Hospital, National University Corporation Okayama University (Headquarters: Kita-ku, Okayama City; President: Yasutomo Nasu), Satoru Mihoshi of the joint research group Shimoetsu Hospital (Akiba-ku, Niigata City) Pharmacist, Assistant Professor Aya F. Ozaki and Professor Pranav Patel of the University of California, Irvine, Professor Keisuke Ishizawa of the Department of Pharmacy, Tokushima University Hospital, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ), Associate Professor Toshihiro Koyama of Nagoya University Graduate School of Informatics, Professor Yoshihiro Yamanishi of the Department of Bioinformatics, Graduate School of Informatics, Nagoya University, and Director Yasunari Isada of the Department of Pharmacology, National Institute of Health Sciences. revealed risk factors for myocarditis induced by immune checkpoint inhibitors.
In particular, it was found that the combined use of immune checkpoint inhibitors and thiazide diuretics increases the risk of developing myocarditis.
These drugs play an important role in the treatment of cardiovascular events, and research on the risk of side effects of individual drugs is expected to lead to the selection of the optimal drug therapy for myocarditis. I’m here. These research results may contribute to the selection of the optimal drug treatment according to the individual patient’s condition, that is, the promotion of individualization of drug treatment.
The results of this research were published as an online version in the International Journal of Cancer, an international medical journal for cancer research, on June 12, 2023.
[Image 2: https://prtimes.jp/i/72793/1560/resize/d72793-1560-82226d643a707fa07a76-2.jpg&s3=72793-1560-6fa52f370d42091a4dba6e7543d7edd4-834×311.jpg] A word from Lecturer Hiroaki Hamano
Through data science research using medical information big data, we believe that we have contributed to the development of treatment strategies for the latest pharmacotherapy, which is currently attracting attention. This research is the result of joint research realized through cooperation with domestic and foreign researchers. We will continue to build evidence that is useful to the world and provide safe medical care to patients.
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◆ Paper information
Paper title: Association between immune checkpoint inhibitor‐induced myocarditis and concomitant use of thiazide diuretics
Japanese title: “Relationship between myocarditis caused by immune checkpoint inhibitors and concomitant use of thiazide diuretics” Published in: International Journal of Cancer (Impact Factor: 7.316) DOI: 10.1002/ijc.34616.
URL: https://pubmed.ncbi.nlm.nih.gov/37306521/
◆ Research funds
This research was supported by the Takeda Science Foundation and scientific research grants.
◆ Detailed research content
A drug that increases the risk of immune checkpoint inhibitor-induced myocarditis has been discovered! ～Returning real-world data to actual clinical practice～
https://www.okayama-u.ac.jp/up_load_files/press_r5/press20230724-1.pdf ◆ Reference
・Okayama University Hospital
https://www.okayama-u.ac.jp/user/hospital/
・Okayama University Hospital Pharmacy Department
https://pharm.hospital.okayama-u.ac.jp/
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◆ Inquiries regarding this matter
Hiroaki Hamano Lecturer, Department of Pharmacy, Okayama University Hospital Okayama University Shikata Campus, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama Prefecture 700-8558
TEL: 086-235-7641
FAX: 086-235-7974
https://pharm.hospital.okayama-u.ac.jp/index.html
-Matters related to cooperation with Okayama University Hospital (Pharmaceutical and medical device companies)-
Okayama University Hospital New Medical Research and Development Center 2-5-1 Shikatacho, Kita Ward, Okayama City, Okayama Prefecture 700-8558 Please inquire about the relevant project from the URL below. http://shin-iryo.hospital.okayama-u.ac.jp/ph_company/
-Matters related to cooperation with Okayama University Hospital (for medical personnel and researchers)-
Okayama University Hospital Research Promotion Division
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2-5-1 Shikatacho, Kita Ward, Okayama City, Okayama Prefecture 700-8558 TEL: 086-235-7983
E-mail: ouh-csnw◎adm.okayama-u.ac.jp
http://shin-iryo.hospital.okayama-u.ac.jp/medical/
-Inquiries regarding Okayama University’s industry-academia-government collaboration-
Okayama University Organization for Research Promotion Headquarters for Industry-Academia-Government Collaboration
1-1-1 Tsushimanaka, Kita-ku, Okayama City, Okayama Prefecture 700-8530 Okayama University Tsushima Campus Main Building 1F TEL: 086-251-8463
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