National University Corporation Kumamoto University Aortic dissection in women: Still underestimated? ~It is clear that there is no difference in the incidence rate between men and women~

National University Corporation Kumamoto University
Aortic dissection in women: still underdiagnosed? ~It is clear that there is no difference in the incidence rate between men and women~ ……
・It has been said that the incidence of acute aortic dissection is higher in men, but since many cases die before arriving at the hospital after onset, a major challenge has been how to conduct accurate epidemiological evaluations that include these cases. . ・Kumamoto University, Miyazaki Prefectural Nobeoka Hospital, and the National Cerebral and Cardiovascular Research Center conducted a population-based study in Nobeoka City, Miyazaki Prefecture, and conducted postmortem CT imaging of patients who died of
out-of-hospital cardiac arrest, thereby determining whether patients died before arriving at the hospital. We identified patients with acute aortic dissection.
・This study revealed for the first time in the world that there is no difference in the incidence of acute aortic dissection between men and women, and that women are more likely to die after onset of the disease before reaching the hospital, so fewer cases reach the hospital. .
[Summary explanation]
Visiting Assistant Professor Kyohei Marume of the Kumamoto University Life Resources Research and Support Center, Professor Kenichi Tsujita of the Department of Cardiovascular Medicine, Kumamoto University, and Chief Nobuyoshi Yamamoto of the Heart and Cerebrovascular Center at Miyazaki Prefectural Nobeoka Hospital (Nobeoka City, Miyazaki Prefecture, Director: Kiminari Terao) The research team, including Chief Director Masakazu Matsuyama and Vice Director Akio Noguchi of the Department of Cardiovascular Medicine at the National Cerebral and Cardiovascular Center (Suita City, Osaka Prefecture, President: Kinya Otsu), found that there is no difference between men and women in the incidence of acute aortic dissection. However, the pre-hospital mortality rate for women was found to be higher than that for men. The results of this research were published in the online version of the medical journal “JACC: Advances” published by the American College of Cardiology on October 2, 2023.
[Development]
This study is the first to show that women with AAD have a higher pre-hospital mortality rate than men with AAD, and there is no difference in the incidence of AAD between men and women. These results will be useful for future research aimed at understanding the pathogenesis of AAD and developing strategies for preventing and treating AAD. Furthermore, in this study, the proportion of AAD was high among female out-of-hospital cardiac arrest cases even at a young age, so it is important to strongly consider AAD when formulating treatment strategies for female out-of-hospital cardiac arrest cases. Masu.
[Paper information]
Paper title: Women With Acute Aortic Dissection Have Higher
Prehospital Mortality Than Men
Author: Kyohei Marume, Teruo Noguchi, Ryota Kaichi, Takao Yano, Masakazu Matsuyama, Yasuhiro Nagamine, Takayuki Mori, Takafumi Mikami, Sou Ikebe, Masafumi Takae, Soichi Komaki, Masanobu Ishii, Reiko Toida, Kazumasa Kurogi, Yosuke Inoue, Hitoshi Matsuda, Shunsuke Murata, Yuriko Nakaoku, Soshiro Ogata, Kunihiro Nishimura, Takahiro Nakashima, Tetsuro Yamaguchi, Nobuyasu Yamamoto, and Kenichi Tsujita
Published magazine: JACC: Advances
DOI: 10.1016/j.jacadv.2023.100623
URL: https://www.jacc.org/doi/abs/10.1016/j.jacadv.2023.100623