National University Corporation Okayama University
[Okayama University] New discovery of one of the mechanisms by which tumors become malignant in malignant peripheral nerve schwannoma ……
March 31, 2024 (Reiwa 6) National University Corporation Okayama University https://www.okayama-u.ac.jp/
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Malignant peripheral nerve sheath tumors are extremely rare malignant tumors, but they are prone to recurrence after surgery and metastasis to multiple organs, and even in modern times with advances in medical technology, they are still one of the malignant tumors with poor prognosis.
We have newly discovered that the interaction of two proteins causes cancer cells to change into a form that makes them more likely to invade and metastasize to their surroundings.
By inhibiting protein interactions, it is expected to be applied to the development of new cancer therapeutics that suppress the malignancy of cancer.
◆Overview
National University Corporation Okayama University (Headquarters: Kita-ku, Okayama City, President: Yasutomo Nasu), Graduate School of Biomedical Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Shota Kashihira, Okayama University Academic Research Institute, Department of Biomedical Sciences (Medical), Tissue Function Repair Professor Tsuyoshi Takarada, Lecturer Chika Takao, Research Associate Professor Daisuke Yamada, Assistant Professor Tatsunori Ohsone, Orthopedics: Professor Toshifumi Ozaki, Lecturer Tomohiro Fujiwara, Professor Toshiyuki Kunisada of the Musculoskeletal Medical Materials Development Course, Nakata of the Musculoskeletal Traumatology Course. A research group led by Associate Professor Eiji and Cell Biology Professor Masakiyo Sakaguchi has discovered one of the mechanisms by which malignant peripheral nerve sheath tumors become malignant.
The research results were published as a Research Article in the international scientific journal “British Journal of Cancer”. This time, we have newly discovered one of the mechanisms by which tumors become malignant due to the interaction between two proteins. It has been suggested that by inhibiting this interaction, it may be possible to suppress the malignancy of cancer, and it is expected that this will be applied to the development of novel cancer treatment drugs.
This information was released by Okayama University on March 27, 2024.
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[Image 4: https://prtimes.jp/i/72793/2090/resize/d72793-2090-266346a981fe0d59ff4b-3.jpg&s3=72793-2090-af7796179ba2d36ab191efda53bccf10-561×635.jpg] ◆A message from graduate student Shota Kakuhira
We have been conducting research to date with the aim of developing a treatment for malignant peripheral nerve sheath tumors, which is one of the malignant tumors with a poor prognosis. I hope that this research will lead to even the slightest possible treatment for patients.
[Image 5: https://prtimes.jp/i/72793/2090/resize/d72793-2090-224a59fb60a0959e0f93-4.jpg&s3=72793-2090-4cdb533b40b47aae53fc66141b0e31e3-143×191.jpg] Shota Kashihira Graduate Student
◆Paper information Paper title: PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumors Publication paper: British Journal of Cancer Author: Shota Takihira, Daisuke Yamada, Tatsunori Osone, Tomoka Takao, Masakiyo Sakaguchi, Michiyuki Hakozaki, Takuto Itano, Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Toshifumi Ozaki, Takeshi Takarada D O I: 10.1038/s41416-024-02632-8 U R L:
https://www.nature.com/articles/s41416-024 -02632-8
◆Research funding This research was supported by Grants-in-Aid for Scientific Research (Fundamental Research C (21K07178, 21K07192, 22K09401), Young Scientists (23K14384), Uehara Memorial Life Science Foundation (202120121), Takeda Science Foundation (2022045851), Kobayashi Cancer Foundation This project was supported by the Japan Society for the Promotion of Science (2022ER001), the Japan Agency for Medical Research and Development (DNW-22022), and the Emergent Research Support Project (JPMJFR225H).
◆Related patent application Title: Protein-protein interaction between PRRX1 and TOP2A and its inhibitory drug Application number: Patent application No. 2022-158515 Filing date: September 30, 2022 Applicant: Okayama University, National University Corporation
◆Detailed research details New discovery of one of the mechanisms by which tumors become malignant in malignant peripheral nerve schwannoma https://www.okayama-u.ac.jp/up_load_files/press_r5/press20240327-3.pdf ◆Reference: Okayama University Faculty of Medicine, Department of Biomedical Sciences (Medicine), Department of Tissue Function Restoration http://regsci.mdps.okayama-u.ac.jp/ Okayama University School of Medicine, School of Medicine https://oumed.
okayama-u.ac.jp/med/・Okayama University Graduate School of Biomedical Sciences https://www.mdps.okayama-u.ac.jp/・Okayama University Hospital https://www.okayama-u. ac.jp/user/hospital/
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◆Contact information for this matter: Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences (School of Medicine) Department of Tissue Function Repair Professor Tsuyoshi Takarada 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama Prefecture 700-8558 Okayama University Shikata Campus Administration Building 7F TEL: 086 -235-7407
http://regsci.mdps.okayama-u.ac.jp/
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