National University Corporation Kumamoto University
Analysis of virological properties of SARS-CoV-2 related coronavirus BANAL-20-236 strain
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・BANAL-20-236 strain (B236 strain), a coronavirus closely related to the new coronavirus (SARS-CoV-2), is a virus isolated from bats in Southeast Asia.
・This study clarified the infectivity of strain B236 in cultured cells and human organoids, and the pathogenicity in hamsters by comparing it with SARS-CoV-2 and its mutants.
・Compared to SARS-CoV-2, the B236 strain was shown to have tissue tropism, with a low proliferative ability in human airway epithelial cells, but a high proliferative ability in human colon organoids. [Presentation summary]
The research consortium “The Genotype to Phenotype Japan
(G2P-Japan)” (Note 1), led by Professor Yoshi Sato of the Department of Systems Virology, Institute of Medical Science, the University of Tokyo, is researching a virus derived from bats that is closely related to SARS-CoV-2. We analyzed the virological properties of the BANAL-20-236 strain (B236 strain) using human airway epithelial cells, colon organoids, a hamster model, etc. Cellular experiments in human respiratory cell models and colon organoids showed that the B236 strain, compared to SARS-CoV-2, has a tropism for colon organoids over human airway epithelial cells. Additionally, infection experiments using a hamster model showed that the B236 strain is less pathogenic than SARS-CoV-2. The results of this research were published in the online version of the British scientific journal “eBioMedicine” on June 4, 2024.
【Presenter】
Institute of Medical Science, The University of Tokyo, Department of Infection and Immunology, Systems Virology Yoshi Sato (Professor) Shigeru Fujita (Graduate student [JSPS Special Researcher]) Arnon Plianchaisuk (Specially Appointed Researcher) Keiya Uryu (Specially Appointed Researcher) Yamasa Daji (Visiting Researcher) Guo Ziyi (Specially Appointed Researcher) Alfredo Jr. Hinay (Specially Appointed Researcher) Yusuke Kosugi (Graduate Student [JSPS Special Researcher]) Chen Li (Graduate Student) Pan Lin (Graduate Student) Guo Yu (Specially Appointed Assistant Professor) Junpei Ito (Associate Professor) Research Consortium “The Genotype to Phenotype Japan (G2P-Japan)” Hokkaido University Graduate School of Medicine Shinya Tanaka (Professor) Takasuke Fukuhara (Professor, Director of G2P-Japan General Incorporated Association) Masumi Tsuda (Associate Professor) Tomokazu Tamura (Lecturer) Riji Suzuki (Assistant Professor) Saori Suzuki (Assistant Professor) Yoshitaka Oda (Assistant Professor) Shun Ito (Graduate Student) Keita Matsuno (Associate Professor),
International Joint Research Institute for Zoonoses, Hokkaido University Izumi Kida (Graduate student) Hokkaido University One Health Research Center Toshinori (Specially Appointed Lecturer) Kyoto University iPS Cell Research Institute (CiRA) Kazuo Takayama (Lecturer) Kiyoka Deguchi (Specific Assistant Professor) Rina Hashimoto (Special Researcher) Yukio Watanabe (Specially Appointed Lecturer) Researcher) Human Retrovirology Joint Research Center Kumamoto University Campus Terumasa Ikeda (Associate Professor) Hesham Nasser (Specially Appointed Assistant Professor)
[Term explanation]
(Note 1) Research consortium “The Genotype to Phenotype Japan (G2P-Japan)” A research team led by Professor Yoshi Sato of the Department of Systems Virology, Institute of Medical Science, The University of Tokyo. Several young researchers and laboratories in Japan are participating and are jointly promoting research to accelerate research. Currently, we are also promoting international collaboration with research teams and consortia from other countries, mainly from the UK.
[Paper information]
-Magazine-eBiomMedicine-Title-Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236-Author-Shigeru Fujita#, Arnon Plianchaisuk#, Kiyoka Deguchi#, Shun Ito#, Tomonori Nao#, Lei Wang, Hesham Nasser, Tomokazu Tamura, Izumi Kimura, Yukie Kashima, Rio Suzuki, Saori Suzuki, Izumi Kida, Masumi Tsuda, Yoshitaka Oda, Rina Hashimoto, Yukio Watanabe, Keiya Uryu, Daichi Yamazaki, Ziyi Guo, Alfredo Jr. Hinay, Yusuke Kosugi, Chen Li, Ban Lin, Yu Guo, Hin Chu, Flora Donati, Sarah Temmam, Marc Eloit, Yuki Yamamoto, Tetsuji Nagamoto, Hiroyuki Asakura, Mami Nagashima, Kenji Teishu, Kazuhisa Yoshimura, Suzuki Jo, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Junpei Ito, Terumasa Ikeda, Shinya Tanaka*, Keita Matsuno*, Takasuke Fukuhara*, Kazuo Takayama*, Yoshi Sato* (#Equal contribution; *Corresponding author)- DOI-
10.1016/j.ebiom.2024.105181-URL-
https://www.sciencedirect.com/science/article/pii/S2352396424002160 ▼Click here for the full press release
https://www.kumamoto-u.ac.jp/whatsnew/seimei-sentankenkyu/20240606
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