National University Corporation Okayama University
[Okayama University] Develops a human organ chip heart model – Expected to contribute to the development of more effective
therapeutic drugs for heart diseases and personalized medicine – ……
August 14, 2024 (Reiwa 6) National University Corporation Okayama University https://www.okayama-u.ac.jp/
[Image 1: https://prtimes.jp/i/72793/2419/resize/d72793-2419-251ee8d6911ea93b57b7-0.jpg&s3=72793-2419-e44158ce45653ea26233358f8a1d7f47-1950×1112.jpg] -Key points of presentation-
We have developed a mini-heart that better mimics the structure and function of the human heart.
Human heart chips can help develop more effective treatments for diseases such as myocardial infarction and heart failure without sacrificing animals.
The use of human iPS cells derived from individuals is expected to contribute to the realization of personalized medicine that takes into account individual differences in drug efficacy and toxicity.
◆Overview Associate Professor Masaru Takahashi and Professor Keiji Naruse of the Faculty of Medicine, Dentistry and Pharmaceutical Sciences (Medical) System Physiology of the National University Corporation Okayama University (Headquarters: Kita-ku, Okayama City, President: Yasutomo Nasu) are researching organ chip technology. We have developed a human mini heart model that applies this. A paper based on the results of this research was published in the British international academic journal “Scientific Reports” on August 8, 2024. Organ chip technology is an innovative technology that reproduces organ functions by co-cultivating multiple types of cells on a chip several centimeters in size with minute flow channels. Until now, the evaluation of the efficacy and toxicity of pharmaceuticals has relied on experimental animals, but the efficacy and toxicity of drugs in animals cannot always be replicated in humans, and animal sacrifice has become a problem.
The widespread use of human heart chips is expected to contribute to the development of more effective therapeutic drugs for heart failure and myocardial infarction, as well as to personalized medicine that takes into account individual differences in drug efficacy.
◆A message from Associate Professor Ken Takahashi
Organ chip technology makes it possible to evaluate the efficacy and toxicity of drugs and create disease models, which previously relied on experimental animals, without sacrificing animals. It has the innovative potential to fundamentally change the methods of
pharmaceutical and medical research.
[Image 2: https://prtimes.jp/i/72793/2419/resize/d72793-2419-9400fc72ac8faf9fcf01-1.jpg&s3=72793-2419-6f9664704144ef71f43dd528188ccfba-200×247.jpg] Associate Professor Satoshi Takahashi
◆Paper information Paper title: Human heart-on-a-chip
microphysiological system comprising endothelial cells, fibroblasts, and iPSC-derived cardiomyocytes Published paper: Scientific Reports Author: Yun Liu, Rumaisa Kamran, Xiaoxia Han, Mengxue Wang, Qiang Li, Daoyue Lai, Keiji Naruse, Ken Takahashi D O I:
10.1038/S41598-024-68275-0 U R L:
https://www.doi.org/10.1038/S41598-024-68275-0
◆Research Funding This research was supported by Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research 20H04518 and 21H04960.
◆Detailed research details Developing a human organ chip heart model – Expected to contribute to the development of more effective
therapeutic drugs for heart diseases and personalized medicine – https://www.okayama-u.ac.jp/up_load_files/press_r6/press20240808-2.pdf ◆Reference
・Okayama University Academic Research Institute, Department of Medicine, Dentistry and Pharmaceutical Sciences (Medical), Department of System Physiology
https://websv.okayama-u.ac.jp/phy2/
・Okayama University School of Medicine
https://oumed.okayama-u.ac.jp/
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◆Contact information for this matter
Associate Professor, Department of Systems Physiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Ken Takahashi Shikata Campus, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama Prefecture 700-8558
TEL: 086-235-7115 FAX: 086-235-7430
https://websv.okayama-u.ac.jp/phy2/?%2F
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