[Sanofi Corporation] The second collaboration between “Cells at Work” and the pharmaceutical company Sanofi. Manga explains type 2 inflammation that causes “hard-to-heal nasal polyps”
*Sanofi Corporation*
Press release: August 21, 2024
**
The second collaboration between “Cells at Work” and the
pharmaceutical company Sanofi. Manga explains type 2 inflammation that causes “hard-to-heal nasal polyps”
*A newly drawn manga will be published on the disease information site “Allergy i” operated by Sanofi from August 21, 2024*
Sanofi, Inc. (Headquarters: Shinjuku-ku, Tokyo, President and CEO: Takahiko Iwaya, hereinafter referred to as “Sanofi”), which
manufactures and sells a treatment for chronic sinusitis accompanied by nasal polyps, has collaborated with “Cells at Work”. original story “Cells at Work”
“Type 2 Inflammation Special Edition” was published today on the disease information site “Allergy i”. (
https://www.allergy-i.jp/hanadumari/hataraku-saibou-index/type2.html )
This is the second installment of this collaboration, the first of which was released last year and was well received, “Cells at Work: Chronic Sinusitis with Nasal Polyps Special Edition” (
https://www.allergy-i.jp/hanadumari/hataraku-saibou/
) explains the mechanism of nasal congestion and the sense of smell. In chronic sinusitis (empyema), multiple “nasal polyps” may occur in both noses. There is a type of refractory chronic sinusitis (eosinophilic sinusitis) that occurs and recurs even after surgery. Recent research has revealed that the cause is closely related to allergic
inflammation called “type 2 inflammation.”
When type 2 inflammation is involved, the immune system, which is supposed to protect the body, becomes overactive and the inflammation persists, causing the nasal polyps that have been removed to recur.
In “Cells at Work! Type 2 Inflammation Special Edition,” this mechanism is explained in a manga.
In recent years, advances have been made in the treatment of nasal diseases, and there are treatment options such as surgery to remove nasal polyps and drug therapy to treat inflammation. First of all, it is important to see a specialist and receive the correct examination and treatment.
The health of your nose is directly connected to the quality of your daily life. Prolonged symptoms can have serious negative effects, especially on patients who are in the early stages of work, such as decreased attention and concentration, headaches, fatigue, and insomnia.
Sanofi’s previous works “Cells at Work: Chronic sinusitis with nasal polyps special edition” and “Cells at Work: Type 2 Inflammation” Through “Special Edition,” we will provide content that explains the disease in an easy-to-understand manner and allows you to have fun learning about the importance of maintaining nasal health with characters from “Cells at Work!”
*Overview of “Cells at Work: Type 2 Inflammation Special Edition”* *Main characters*
Cells (ILC2, helper T cells) that cause type 2 inflammation, which is the cause of nasal polyps, appear.
ILC2 (innate lymphocytes)
ILC2 (innate lymphocytes): Lymphocytes that are activated during parasitic infections and allergic diseases and produce interleukins such as IL-5 and IL-13. It was discovered in Japan in 2010.
Helper T cells (Th2)
Helper T cell (Th2): A commander who receives news of an invading foreign enemy and decides on a strategy to accurately attack the invading enemy based on information about what the foreign enemy is like.
Manga: Kairemeku Supervision: Akane Shimizu (“Cells at Work!”) Medical supervision:
Professor, Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Fukui
Professor Kazuyo Moro, Department of Biodefense, Osaka University Graduate School of Medicine
Public site: Disease information site “Allergy i” (
https://www.allergy-i.jp/hanadumari/hataraku-saibou-index/type2.html )
* What is “chronic sinusitis with nasal polyps”? *
Image of nasal polyps and intranasal photos
Nasal polyps are fleshy proliferative lesions that form on the nasal mucosa, and are also called nasal polyps. When you hear the word “nasal polyps,” you may think, “How can you get polyps in your nose?” However, in cases of chronic sinusitis (empyema) that are intractable, polyp-like ” There are cases in which “bumps” can form inside the nose.
It is said that 10 to 20% of patients with chronic sinusitis, or approximately 200,000 Japanese people, have nasal polyps (i, ii). Many nasal polyps tend to form on both sides of the nose, so they must be surgically removed. If type 2 inflammation is involved, there are cases where the nasal polyps that have been removed may recur. It is important to receive continued treatment such as drug therapy and surgery from a specialist.
Symptoms of chronic sinusitis with nasal polyps include nasal congestion, runny nose, loss of smell, and headache. However, even if these symptoms are present, it is difficult to distinguish them from general rhinitis or hay fever, and patients often become accustomed to the symptoms and do not seek professional treatment.
If symptoms persist, the patient’s health-related
QOL (an index that evaluates multiple items such as productivity and activities of daily living) may be impaired (iii, iv, v), making it impossible to enjoy meals, and causing sleep deprivation and fatigue.
Many patients with chronic sinusitis with nasal polyps also suffer from asthma, and the asthma in these patients is often more severe and difficult to treat.
Among chronic sinusitis accompanied by nasal polyps, eosinophilic sinusitis is designated as a designated intractable disease, and patients who meet certain criteria can receive subsidies for medical expenses.
*What is “Cells at Work”?*
White blood cells, red blood cells, platelets, macrophages, etc. The number of human cells is approximately 60 trillion! They all work tirelessly inside the body. There was an unknown drama between the cells! This is a cell anthropomorphic fantasy drawn by Akane Shimizu, a former member of the Sirius Newcomer Award.
*What is Sanofi’s information site for allergy patients, “Allergy i”?* This is an information site that provides information on diseases such as atopic dermatitis, bronchial asthma, and sinusitis, as well as support content for patients.
On the page “For those who are worried about stuffy nose and inability to smell,” you can find not only the newly created web video, but also tools that allow you to self-check your sense of smell, stories from experts, searches for specialists you can consult, and patient experiences. A lot of information, including interviews, is updated and published from time to time. For more information, please click on the URL below and refer to the contents.
URL: https://www.allergy-i.jp/hanadumari/sinusitis/
* About Sanofi Corporation *
Sanofi is an innovative, global healthcare company driven by an unwavering mission to discover the miracles of science that improve people’s lives. Our employees in approximately 100 countries work hard every day to transform healthcare and turn the impossible into possible. With social responsibility and sustainability at the heart of our company, we develop and deliver breakthrough medicines and life-saving vaccines to millions of people around the world. For more information on Sanofi Corporation, a Japanese corporation, please visit http://www.sanofi.co.jp
*Reference source*
i Shigeharu Fujieda, et al. Allergy. 2015;64:38-45
ii Satoshi Ogino, et al. Otorhinolaryngology. 1991;Supplementary 41:113-121 iii Khan A, et al. The GALEN sinusitis cohort: impact on quality of life in patients with chronic rhinosinusitis with nasal polyps (CRSwNP):1536. Allergy: European Journal of Allergy and Clinical Immunology 70 (2015): 282-83. [Epub ahead of print].
iv Kumar K, Shah A. Effect of Nasal Polyposis on Nocturnal Sleep Disturbances, Daytime Sleepiness, and Sleep Specific Quality of Life :Disturbances in Patients Presenting with Allergic Rhinitis – Abstract 46. Annals of Allergy, Asthma and Immunology. 2014 Nov;113(5)A17.v Radenne F, et al. Quality of life in nasal polyposis. J Allergy Clin Immunol. 1999 Jul;104(1):79-84.