[Hamamatsu Photonics Co., Ltd.] Develops a next-generation cell analysis device using high-speed 3D fluorescence imaging that improves the efficiency of drug discovery screening
*Hamamatsu Photonics Co., Ltd.*
Press release: September 9, 2024
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Developing a next-generation cell analysis device using high-speed 3D fluorescence imaging to improve the efficiency of drug discovery screening
*Orders start from Tuesday, September 10th*
CYTOQUBE Light Sheet Microplate Cytometer C15200-01RGBU
By applying our image processing and measurement device design technology that we have cultivated over many years and our proprietary Zyncscan(R) technology (*1), we are able to create cells that mimic conditions physiologically close to those of living organisms. A cell analysis device that quickly acquires 3D fluorescence images of a population while simultaneously analyzing the size, shape, number, and condition of cells and cell populations.
We have developed the CYTOQUBE(R) Light Sheet Microplate (*2) Cytometer (*3) C15200-01RGBU.
This product is expected to be used in the drug discovery screening (*4) process, which is one of the initial steps in drug discovery research and development. Drug discovery screening is an important process that affects the probability of success in drug discovery research and development, and requires efficient and accurate evaluation of multiple new drug candidates. This product significantly reduces the time required to acquire and analyze 3D fluorescence images, especially for 3D cell populations, and at the same time enables accurate measurements, dramatically improving the efficiency of drug discovery screening.
Orders for this product will begin on September 10th (Tuesday) from domestic and overseas pharmaceutical manufacturers and research institutions. In addition, the 83rd Annual Meeting will be held at the Fukuoka International Conference Center/Fukuoka Marine Messe (Hakata Ward, Fukuoka City, Fukuoka Prefecture) for three days from September 19th (Thursday).
We will exhibit at the Japanese Cancer Society Academic Meeting.
*1
Zyncscan technology: A unique measurement technology that achieves high-speed construction and analysis of 3D fluorescence images excluding autofluorescence by combining optical technology centered on an optical system using light sheet illumination and image processing technology.
*2 Microplate: A flat measurement container with many wells lined up. *3 Cytometer: A device that quantitatively measures the size, shape, function, etc. of individual cells from a cell population.
*4 Drug discovery screening: The process of evaluating and screening new drug candidates for their effectiveness and safety.
-Development background-
In the drug discovery screening process using cells, cell populations that more accurately reflect the physiological state of the organism are used for better evaluation, and in recent years, 3D cell populations with a 3D structure have been used. Ratings are
increasing.
Currently, drug discovery screening using 3D cell populations is mainly performed using equipment equipped with fluorescence microscope imaging, but it requires a great deal of time and effort. To solve this problem, we have been working on the development of a device that significantly reduces the time required to acquire and analyze 3D fluorescence images and improves the efficiency of drug discovery screening.
-Product overview-
This product is a cell analysis device that quickly acquires 3D fluorescence images of cells and cell populations on microplates, and at the same time analyzes the size, shape, number, and condition of cells and cell populations.
By applying our proprietary Zyncscan technology and optimizing camera and sample movement movements, we can acquire 3D fluorescence images of cells quickly and accurately, and optimize hardware and software image processing. We realized parallel processing of image acquisition and analysis. Furthermore, the previously complicated image
acquisition and analysis condition settings have been simplified, making fast, simple, and accurate measurements possible.
As a result, we succeeded in developing a light sheet microplate cytometer that can quickly, easily, and accurately acquire 3D fluorescence images of cells on microplates and analyze the size, shape, number, and condition of cells and cell populations. I did. By using this product in the research and development of drug discovery, including cancer treatment drugs, it will significantly improve the efficiency of the drug discovery screening process that analyzes the effects of new drug candidates on cells and cell populations that are physiologically similar to living organisms. It is expected that this will contribute to accelerating drug discovery research.
Going forward, we will continue to expand sales of this product and respond to market demands.
-Main features of the product-
1. Significantly shortens the time from acquiring 3D fluorescence images of cells/cell populations to outputting analysis results Acquiring and analyzing 3D fluorescence images using conventional methods takes at least several hours. In addition to high-speed image acquisition, this product performs parallel processing of image acquisition and analysis, making it possible to complete the process from acquiring 3D fluorescence images of 3D cell populations to outputting analysis results in as little as 21 minutes using 3 colors.
2. Simple configuration and user interface
Conventional methods for acquiring and analyzing 3D fluorescence images required complicated settings. This product utilizes Zyncscan technology and a sophisticated software user interface to reduce the burden on the user with simple condition settings and intuitive operation.
3. Accurate image acquisition and analysis
By automatically removing fluorescence originating from sources other than cells that would interfere with accurate analysis, it is possible to obtain and analyze accurate fluorescence images of cells and cell populations.
How this product works using Zyncscan technology
A sheet of excitation light (light sheet excitation light) is irradiated from directly below the sample, and an XZ tomographic image is acquired from diagonally downward.
By continuously acquiring XZ tomographic images while moving the microplate in a direction perpendicular to the light sheet excitation light, it is possible to achieve an overwhelming throughput of 3. Construct a dimensional fluorescence image. Additionally, in parallel with the acquisition of XZ tomographic images, fluorescence
originating from sources other than cells (background fluorescence) is removed in real time.
Main specifications
-Product information page-
https://www.hamamatsu.com/jp/ja/product/life-science-and-medical-systems/light-sheet-microplate-cytometer.html?utm_source=webrelease&utm_medium=referral&utm_campaign=20240909_sys-inf
-Our website-
https://www.hamamatsu.com/jp/ja.html
-Contact information regarding this matter-
■For those in the press Hamamatsu Photonics Co., Ltd.
Corporate Communication Department Michitaka Nozue
Nippon Life Hamamatsu Ekimae Building, 325-6 Sunayama-cho, Chuo-ku, Hamamatsu 430-8587
TEL: 053-452-2141 FAX: 053-456-7888 E-mail: nozue-m@hq.hpk.co.jp After hours, please call 080-8262-0374 on your mobile phone. ■General public Hamamatsu Photonics Co., Ltd.
Systems Division Sales Promotion Department CYTOQUBE Responsible 812 Jokocho, Chuo-ku, Hamamatsu 431-3196
TEL: 053-435-1560 FAX: 053-456-7888 E-mail:sales@sys.hpk.co.jp