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  • [Shiseido Co., Ltd.] Shiseido elucidated the relationship between skin elasticity and capillaries-discovered that yeast cell extract helps collagen production-

[Shiseido Co., Ltd.] Shiseido elucidated the relationship between skin elasticity and capillaries-discovered that yeast cell extract helps collagen production-

Shiseido Co., Ltd. Shiseido elucidates the relationship between skin elasticity and capillaries-discovered that yeast cell extract helps collagen production- …………………………………………………………………………………………… Shiseido has clarified for the first time that capillaries are involved in the elasticity of the skin using a unique technology that observes the blood vessels inside the skin in three dimensions. We have also found that yeast cell extract has the effect of promoting the production of collagen, which is important for maintaining healthy capillaries and maintaining skin elasticity. In the future, we will use the results of this research to develop skin care products that prevent skin worries caused by skin elasticity such as wrinkles and sagging and lead to firm skin. 一部 Some of the results of this research were presented at the International Federation of Cosmetic Engineers (IFSCC *) Milan Intermediate Conference 2019 (2019/9 / 30-10 / 2) and won the Grand Prize. It will be announced at “North American Vascular Biology Organization” (2019/10 / 27-31). * IFSCC (The International Federation of Societies of Cosmetic Chemists): An international organization where cosmetic engineers from around the world gather to work on the development of more sophisticated and safe cosmetic technologies. [Image 1

《Relationship between skin elasticity and capillaries》 Using our original blood vessel 3D visualization technology, we investigated the relationship between the elasticity of the skin and the state of the capillaries. In places where we show high elasticity like the skin of our 20s, the capillaries are thick and dense. (Figures 2 and 3). We also observed the production of collagen around the capillaries (Figure 1). This suggests that capillaries may be involved in maintaining skin elasticity. [Image 2

《Search for drugs that increase integrin α5》 In capillaries, integrin α5, which is an important factor for maintaining a good state of capillaries, exists, and the expression of this factor is thought to affect collagen production inside the skin. In this study, we found that the expression level of integrin α5 in capillaries decreased with age, and the skin elasticity also decreased. This result suggests that maintaining the expression of integrin α5 in capillaries is important for skin elasticity. Therefore, as a result of searching for a drug that increases integrin α5, it was confirmed that the yeast cell extract (Figure 4) extracted from a yeast of Saccharomyces by a special method had an effect (Figure 5). From this, it was found that the yeast cell extract has the effect of increasing the expression of integrin α5, which decreases with aging, to promote collagen production and produce firm skin. [Image 3

[Reference: Shiseido’s 3D blood vessel visualization technology] Shiseido has worked on research that has focused on the relationship between capillaries and skin, and that the decrease in capillaries due to aging and ultraviolet rays is one of the fundamental causes of skin aging. I have reported. However, the conventional method alone could not fully understand the complex network structure of capillaries inside the skin. Therefore, in 2018, we developed a unique technology to visualize capillaries inside the skin in a three-dimensional manner with a wide field of view using a technique called tissue transparency. Using this technology, we discovered that capillaries form a very dense network structure that supports the skin as a scaffold (Fig. 6), and this time elucidated the relationship between skin elasticity and capillaries. I was able to. [Image 4

[Reference material] Related past technical releases ・ 2019: “Best Award” at the International Cosmetic Engineers Association (IFSCC) Milan Intermediate Conference 2019 www.shiseidogroup.jp/news/detail.html?n=00000000002769&rt_pr=tre78 ・ 2018: Shiseido succeeded in 3D visualization of abnormal blood vessel structure inside the skin of the stain www.shiseidogroup.jp/news/detail.html?n=00000000002498&rt_pr=tre78 ・ 2017: Successful visualization of capillaries without cutting the skin www.shiseidogroup.jp/news/detail.html?n=00000000002265&rt_pr=tre78
▼ News Release www.shiseidogroup.jp/news/detail.html?n=00000000002780&rt_pr=tre78
▼ Shiseido Group Company Information Site www.shiseidogroup.jp/?rt_pr=tre78

For more information about this release(Japanese):
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